Search results for "Acides nucléiques"

Des outils moléculaires toujours plus multifonctionnels pour l’étude de structures alternatives d’acides nucléiques.

2022

G-Quadruplexes (G4) are non-canonical secondary structure found throughout the genome and transcriptome in guanine rich sequences. Their involvement in biologically relevant processes (telomeres maintenance, transcription and translation) has been demonstrated, yet their role is still not fully elucidated. To investigate their role, we focus on the development of biomimetic molecular tools that could be used either to isolate G4 by new generation sequencing techniques or visualize them directly in cell. This class of molecular tools (TASQ: Template Assembled Synthetic Quartet) is composed by four guanine moieties linked to a central template thanks to spacers of different chemical nature. I…